Additional file 2 of Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity

Additional file 2: Table S1. All Instrumental variables used for gut microbiota in the MR analysis. Table S2. Full results of primary MR analysis between bacterial taxa and all-grade irAEs. Table S3. Full results of primary MR analysis between bacterial taxa and high-grade irAEs. Table S4. Results of ΜR PRESS Global test. Table S5. Instrumental variables for irAEs in the reverse MR analysis. Table S6. Results of reverse MR analysis between all-grade irAEs and the identified significant gut bacterial taxa. Table S7. Results of reverse MR analysis between high-grade irAEs and the identified significant gut bacterial taxa. Table S8. Results of heterogeneity and horizontal pleiotropy analysis in reverse MR analysis. Table S9. PhenoScanner results of instrumental variables used for significant bacterial taxa in the MR analysis. Table S10. Description of data sets used for weight-associated anthropometric and lifestyle factors in univariable MR analysis. Table S11. Multivariate MR estimates between gut microbiota (adjusted for BMI) and irAEs.

附加文件2：表S1。孟德尔随机化（Mendelian Randomization, MR）分析中用于肠道菌群的全部工具变量。表S2。细菌分类群与全级免疫相关不良事件（immune-related adverse events, irAEs）之间的主要孟德尔随机化分析完整结果。表S3。细菌分类群与高级别免疫相关不良事件之间的主要孟德尔随机化分析完整结果。表S4。MR-PRESS全局检验结果。表S5。反向孟德尔随机化分析中用于免疫相关不良事件的工具变量。表S6。全级免疫相关不良事件与已鉴定的显著肠道细菌分类群之间的反向孟德尔随机化分析结果。表S7。高级别免疫相关不良事件与已鉴定的显著肠道细菌分类群之间的反向孟德尔随机化分析结果。表S8。反向孟德尔随机化分析中的异质性与水平多效性分析结果。表S9。孟德尔随机化分析中用于显著细菌分类群的工具变量的PhenoScanner分析结果。表S10。单变量孟德尔随机化分析中用于体重相关人体测量学指标与生活方式因素的数据集说明。表S11。校正体重指数（Body Mass Index, BMI）后的肠道菌群与免疫相关不良事件之间的多变量孟德尔随机化效应估计值。