Retest variability for 2TCM, Logan with full input, and Logan with PBIF, respectively.

In the present study, results with Logan and the PBIF (variability: 16%; ICC = 0.89) were nearly identical to those obtained with Logan and the full input function. VT values obtained with 2TCM, Logan with full input and Logan with PBIF were strongly correlated (scatter plots are shown in Figure S1).

本研究中，采用洛根分析法（Logan）结合PBIF得到的结果（变异度：16%；组内相关系数（Intraclass Correlation Coefficient, ICC）= 0.89）与采用洛根分析法结合完整输入函数得到的结果几乎一致。通过两组织室模型（2TCM）、完整输入函数结合洛根分析法以及PBIF结合洛根分析法得到的分布容积（Volume of Distribution, VT）值均具有较强的相关性，其散点图详见补充图S1。