Additional file 2 of Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Additional file 2: Table S2. WRN KO and WRN inhibitor treatment validated cell lines. A. List of DepMap cell lines previously for WRN survival dependence using WRN KO assays. DepMap_ID: DepMap cell line id. Cell_line_name: Name of cell line. Author: name of publication WRN KO assay was performed in. WRN_dependence: outcome of WRN KO (TRUE indicates that WRN was essential for survival and FALSE indicates that it was not). B. Mutations found in MMR genes and KMT2D in cell lines in A. C-D. Shows a list of DepMap cell lines (C) and their MMR gene and KMT2D (D) mutations treated with WRN inhibitors.

附加文件2：表S2。WRN基因敲除（WRN KO）及WRN抑制剂处理验证的细胞系。A. 既往通过WRN基因敲除实验评估WRN生存依赖性的DepMap细胞系列表。DepMap_ID：DepMap细胞系ID。Cell_line_name：细胞系名称。Author：开展WRN基因敲除实验的文献作者。WRN_dependence：WRN基因敲除的结果（TRUE表示WRN对细胞生存至关重要，FALSE表示非必需）。B. A部分细胞系中错配修复基因（MMR genes）及KMT2D的突变情况。C-D. 展示经WRN抑制剂处理的DepMap细胞系列表（C）及其错配修复基因与KMT2D突变情况（D）。