Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner

We demonstrated that Pyk2 is a novel fear memory suppressor molecule and Pyk2 null mice provide a model for understanding fear-related disorders. Study for Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner used RNA-seq experiments of hippocampus from WT,Pyk2 KO at basal conditioning before fear conditioning.

本研究证实，富脯氨酸酪氨酸激酶2（Pyk2）是一种新型恐惧记忆抑制分子，Pyk2敲除小鼠可作为探究恐惧相关疾病的理想动物模型。为阐明Pyk2以不依赖自身磷酸化的方式抑制情境恐惧记忆的分子机制，本研究对恐惧条件化前的基础条件化阶段的野生型（Wild Type，简称WT）与Pyk2敲除（Knock Out，简称KO）小鼠的海马体组织开展了RNA测序（RNA sequencing，简称RNA-seq）实验。