Glioblastoma cells treated with MI3 or DMSO

Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2. RNA-seq of primary glioblastoma cells with MI3 treatment or control after 7 days of treatment

自我更新是胶质母细胞瘤细胞的关键特性，其实现依赖于染色质调控因子与转录因子的协同有序功能。鉴定可靶向的自我更新表观遗传机制，可为开发针对这种普遍致命癌症的新型有效治疗手段奠定重要基础。本研究揭示了一条由组蛋白变体macroH2A2（histone variant macroH2A2）介导的、可靶向的自我更新表观遗传轴。本研究对经MI3处理或对照处理7天的原代胶质母细胞瘤细胞进行了RNA测序（RNA-seq）。