GREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression

Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationship between the bone marrow adipose microenvironment and disease progression is still not well understood.

儿童B细胞急性淋巴细胞白血病（B-cell acute lymphocytic leukemia, B-ALL）中，复发与疾病进展是导致治疗失败及后续死亡的主要诱因。在诊断阶段及治疗过程中，儿童白血病患者体内常可观察到骨髓脂肪微环境。然而，目前学界对于骨髓脂肪微环境与疾病进展之间的关联仍未完全明晰。