Supplementary Data from A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck

Supplementary Tables 5-8. Supplementary Table 5. Unconditional and conditional analyses of 4 low LD SNPs after clump analysis using overall SCCHN data, conditioning on any three other SNPs in the table. Supplementary Table 6. Unconditional and conditional analyses of SNPs with meta-analysis P-value < 5e-08 conditioning on the two lead SNPs (rs10462706 and rs1049055) in the two loci associated with oral cancer risk. Supplementary Table 7. Unconditional and conditional analyses of SNPs with meta-analysis P-value < 5e-08 with oropharyngeal cancer risk, conditioning on the six SNPs (rs41258944, rs28366328 rs73730372, rs9469220, rs144112342, and rs2194452) located in the two loci reported to associated with oropharyngeal cancer risk. Supplementary Table 8. Unconditional and conditional analyses of SNPs with meta-analysis P-value < 5e-08 with hypo-pharyngeal and laryngeal cancer risk, conditioning on the lead SNPs (rs14202170) at loci 18q22.

补充表5至8。
补充表5：基于整体头颈部鳞状细胞癌（Squamous Cell Carcinoma of the Head and Neck, SCCHN）数据开展连锁不平衡聚类分析后，针对4个低连锁不平衡（Linkage Disequilibrium, LD）单核苷酸多态性（Single Nucleotide Polymorphism, SNP）开展无条件关联分析与条件关联分析，其中条件关联分析以该表中其余任意3个SNP作为校正变量。
补充表6：针对荟萃分析P值小于5×10^-8的单核苷酸多态性，以与口腔癌风险相关的两个位点上的领先SNP（rs10462706和rs1049055）作为校正变量，开展无条件关联分析与条件关联分析。
补充表7：针对荟萃分析P值小于5×10^-8且与口咽癌风险相关的单核苷酸多态性，以已报道的与口咽癌风险相关的两个位点上的6个SNP（rs41258944、rs28366328、rs73730372、rs9469220、rs144112342及rs2194452）作为校正变量，开展无条件关联分析与条件关联分析。
补充表8：针对荟萃分析P值小于5×10^-8且与下咽癌及喉癌风险相关的单核苷酸多态性，以18q22位点上的领先SNP（rs14202170）作为校正变量，开展无条件关联分析与条件关联分析。