Temporal stability of the salivary microbiome and its association with salivary markers of oxidative stress

Salivary markers of oxidative stress are associated with periodontal status and are altered in patients with periodontitis or caries. It has been hypothesized that the composition of oral microbiome and the presence of specific bacterial species might be associated with some salivary markers of oxidative stress. The day to day variability of salivary markers of oxidative stress has been described. More detailed studies are needed for the assessment of salivary microbiome stability. The objective of the present study is to study temporal stability of saliva microbiome and to analyze its association to variations of salivary markers of oxidative stress.

氧化应激唾液标志物（salivary markers of oxidative stress）与牙周状态密切相关，且在牙周炎或龋病患者体内呈现异常改变。已有研究假说提出，口腔微生物组（oral microbiome）的组成结构与特定细菌类群的存在，可能与部分氧化应激唾液标志物存在关联。目前已有研究对氧化应激唾液标志物的日间变异情况进行了报道，针对唾液微生物组（salivary microbiome）稳定性的评估仍需开展更为深入细致的研究。本研究旨在探究唾液微生物组的时间稳定性，并分析其与氧化应激唾液标志物变化之间的关联。