Transcriptome of skin biopsies from Hidradenitis Suppurativa (HS) patients with anti-TNFalpha therapy.. Transcriptome of skin biopsies from Hidradenitis Suppurativa (HS) patients with anti-TNFalpha therapy.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with significant morbidity. The pathogenesis remains incompletely understood although immune dysregulation plays an important role. It is challenging to treat and approximately 50% of patients respond clinically to adalimumab, the only licensed treatment. Overall design: We completed bulk RNA-sequencing on lesional and non-lesional skin samples of patients before and after 12-weeks treatment with adalimumab.

化脓性汗腺炎（Hidradenitis suppurativa, HS）是一种慢性炎症性皮肤病，可导致显著的疾病负担。尽管免疫失调在其发病过程中发挥了重要作用，但目前该病的发病机制尚未完全阐明。该病治疗难度较大，阿达木单抗（adalimumab）是目前唯一获批的治疗药物，约50%的患者可对其产生临床应答。
实验整体设计：我们对接受阿达木单抗治疗12周前后的患者皮损及非皮损皮肤样本开展了批量RNA测序（bulk RNA-sequencing）。