Transcriptome profiles of female and male mouse liver

Sexual dimorphism of gene expression is commonly observed in mammalian tissues, including liver. To assess sexual dimorphisms in gene expression, we profiled the transcriptome of liver tissue from 20-week old male and female mice of the C57BL/6N (B6) and C3H/HeN (C3) inbred mouse strains using RNA-seq. These two inbred mouse strains exhibit phenotypic differences in liver biology, as they are at opposite ends of the spectrum of spontaneous hepatocellular carcinoma incidence; C3 mice are highly susceptible to develop spontaneous liver tumors as a function of age, while B6 mice are extremely resistant. Overall, these datasets provide insight into the underlying gene expression patterns that should be considered when assessing sex differences in mouse liver. Transcriptome profiles of adult female and male liver tissues from C57BL/6N and C3H/HeN mice, using RNA-seq基因表达的性别二态性在包括肝脏在内的哺乳动物组织中普遍存在。为评估基因表达的性别二态性，本研究采用RNA测序（RNA-seq）技术，对C57BL/6N（简称B6）与C3H/HeN（简称C3）两个近交小鼠品系20周龄雌雄小鼠的肝脏组织转录组进行了测序分析。这两个近交小鼠品系在肝脏生物学特征上存在显著表型差异：二者在自发性肝细胞癌发病率上处于光谱的两极——C3小鼠随年龄增长极易自发罹患肝脏肿瘤，而B6小鼠则具有极强的肿瘤抗性。总体而言，本数据集可为评估小鼠肝脏性别差异时所需考量的潜在基因表达模式提供重要参考依据。本研究采用RNA测序技术，获取了C57BL/6N与C3H/HeN品系成年雌雄小鼠肝脏组织的转录组图谱。