Versatile Route to Arylated Fluoroalkyl Bromide Building Blocks

New difunctionalized and fluoroalkylated silyl reagents have been prepared that react with silver and copper salts to afford active catalysts that can be used to synthesize arylated fluoroalkyl bromide building blocks. It has been shown that the [(phen)­Ag­(CF2)nBr] intermediates are capable of transferring both the phenanthroline ligand and the fluoroalkyl bromide chain to copper iodide, eliminating the need for a preligated copper salt precursor. The methodology is compatible with various chain lengths of the fluoroalkyl halide functionality.

现已制备得到新型双官能化氟烷基化硅基试剂，该试剂可与银盐、铜盐反应得到活性催化剂，用于合成芳基化氟烷基溴合成砌块。研究表明，[(菲咯啉(phenanthroline，简称phen))合银(CF₂)ₙBr]中间体可将菲咯啉配体与氟烷基溴链同时转移至碘化铜中，无需使用预先配位的铜盐前驱体。该合成方法可兼容不同链长的氟烷基卤化物官能团。