Dysregulated Genes, Biological pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A preliminary analysis

We report the differentially expressed genes among people with PAD Progression, PAD no progression compared to non-PAD. Overall design: Gastrocnemius muscle biopsies were obtained from 7 people with PAD progression, 6 with PAD- and no progression, and 7 people without PAD matched by sex and race. This study characterized differential gene expression in gastrocnemius muscle biopsies from people with PAD compared to those without PAD. Differences in gene expression were compared between people with PAD who had progression of disease over six months versus those without progression of disease over six months.

本研究报道了外周动脉疾病（Peripheral Arterial Disease, PAD）进展组、PAD未进展组与非PAD组人群的差异表达基因。实验设计概述：本研究从7名PAD进展患者、6名PAD未进展患者，以及7名经性别与种族匹配的非PAD受试者中采集腓肠肌活检组织。本研究对PAD患者与非PAD受试者的腓肠肌活检组织的差异基因表达特征进行了表征，并比较了6个月内出现疾病进展的PAD患者与同期疾病未进展的PAD患者之间的基因表达差异。