Genomic characterization of the MPNST. Homo sapiens

Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. By characterizing recurrent gene copy number aberrations, we gain insight into the most altered pathways with the purpose of scanning possible therapeutic targets. Overall design: We conducted a microarray-based comparative genomic hybridization profiling of two cohorts of primary MPNST tissue samples including 25 patients treated at The University of Texas MD Anderson Cancer Center and 26 patients from Tianjin Cancer Hospital. All samples had at least 90% tumor content. Commercially available normal genomic DNAs were used as control.

恶性外周神经鞘瘤（Malignant peripheral nerve sheath tumor, MPNST）是一类缺乏有效治疗策略的罕见肉瘤。通过解析复发性基因拷贝数变异的特征，我们得以阐明发生显著改变的核心通路，以期筛选潜在治疗靶点。
实验设计：我们对两队列原发性MPNST组织样本开展基于微阵列的比较基因组杂交谱分析，其中纳入德克萨斯大学MD安德森癌症中心收治的25例患者样本，以及天津肿瘤医院的26例患者样本。所有样本的肿瘤细胞占比均不低于90%，并采用市售正常基因组DNA作为对照。