Supplementary Material for: Comparison of Solute Clearance, Hospitalization Rate, and Aortic Arch Calcification between Online Hemodiafiltration and High-Flux Hemodialysis: A 6-Year Observational Study

<b><i>Background/Aims:</i></b> Studies on the long-term clinical benefits of hemodiafiltration (HDF) and high-flux hemodialysis (HFHD) are very limited. This study aimed to investigate the hospitalization rate and aortic arch calcification (AAC) of these two dialysis modalities over 6 years. <b><i>Methods:</i></b> Participants who received regular HDF and HFHD in one hospital-facilitated hemodialysis center were prospectively enrolled after matching for age, sex, and diabetes between January 2009 and December 2014. Medical records were reviewed retrospectively on demographics, laboratory variables, calcified scores in aortic arch measured by chest radiography, and rates of hospital admission. Cox proportional hazard regression and linear regression were used to obtain the outcome results. <b><i>Results:</i></b> The HDF and HFHD groups consisted of 108 and 102 participants, respectively. Levels of laboratory variables including small soluble solutes and Kt/V were not statistically different over the 6-year period between the HDF and HFHD groups. Calcified scores of the aortic arch increased over 6 years in both groups. The changes in the mean calcified scores were significant when compared between the two groups (0.44–1.82 in HFHD, 0.79–1.8 in HDF, respectively, <i>p</i> = 0.008). Hospitalization rates were 735 per 1,000 patients in the HDF group and 852 per 1,000 patients in the HFHD group, respectively. No significant difference was observed in frequency and days of hospitalization between HDF and HFHD. <b><i>Conclusion:</i></b> Hospitalization rates and AAC were observed to be equal for HDF and HFHD.

<b><i>背景与目的：</i></b> 目前针对血液透析滤过（hemodiafiltration, HDF）与高通量血液透析（high-flux hemodialysis, HFHD）的长期临床获益相关研究仍较为匮乏。本研究旨在探究两种透析方式在6年随访期内的患者住院率与主动脉弓钙化（aortic arch calcification, AAC）情况。<b><i>方法：</i></b> 本研究于2009年1月至2014年12月期间，在某医院附属血液透析中心纳入规律接受血液透析滤过或高通量血液透析的受试者，按年龄、性别及糖尿病史进行匹配后完成入组。本研究回顾性查阅受试者的病历资料，包括人口学特征、实验室指标、胸部X线摄片测定的主动脉弓钙化评分，以及住院率数据。采用Cox比例风险回归与线性回归分析获取研究结局数据。<b><i>结果：</i></b> 血液透析滤过组与高通量血液透析组分别纳入108例与102例受试者。随访6年期间，两组受试者的实验室指标（包括小分子可溶性溶质及Kt/V）水平无统计学差异。两组受试者的主动脉弓钙化评分均随随访时间延长呈升高趋势。两组的平均钙化评分变化幅度存在统计学差异（高通量血液透析组为0.44~1.82，血液透析滤过组为0.79~1.8，*p*=0.008）。血液透析滤过组与高通量血液透析组的住院率分别为每千患者735例次与每千患者852例次。两组的住院频次与住院时长均无统计学差异。<b><i>结论：</i></b> 本研究结果显示，血液透析滤过与高通量血液透析的患者住院率及主动脉弓钙化程度无显著差异。