Quantitative proteomic profiling of ruptured and unruptured brain arteriovenous malformations

This study presents a quantitative proteomic analysis of human brain arteriovenous malformation (AVM) tissues with different rupture status. Surgically resected AVM specimens from ruptured and unruptured lesions were subjected to protein extraction, enzymatic digestion, and liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis. The dataset aims to characterize proteomic alterations associated with hemorrhagic presentation and to identify molecular pathways potentially involved in vascular instability. Raw mass spectrometry data and processed identification results are provided to facilitate data reuse and integrative multi-omics analyses.

本研究针对不同破裂状态的人脑动静脉畸形（arteriovenous malformation, AVM）组织开展了定量蛋白质组学分析。研究收集了破裂与未破裂病灶的手术切除AVM标本，并对其进行蛋白质提取、酶解以及液相色谱-串联质谱（liquid chromatography–tandem mass spectrometry, LC-MS/MS）分析。本数据集旨在表征与出血性表现相关的蛋白质组学改变，并识别可能参与血管不稳定过程的分子通路。数据集提供原始质谱数据与经过处理的鉴定结果，以促进数据复用及整合多组学分析。