crystal structure of VDR in complex with D-Bishomo-1a,25-dihydroxyvitamin D3 Analog 54

crystal structure of VDR in complex with D-Bishomo-1a,25-dihydroxyvitamin D3 Analog 54 Descriptor: (1~{R},3~{R})-5-[(2~{E})-2-[(4~{a}~{R},5~{S},9~{a}~{S})-4~{a}-methyl-5-[(2~{R})-6-methyl-6-oxidanyl-heptan-2-yl]-3,4,5,6,7,8,9,9~{a}-octahydro-2~{H}-benzo[7]annulen-1-ylidene]ethylidene]cyclohexane-1,3-diol, Nuclear receptor coactivator 2, Vitamin D3 receptor A Authors: Rochel, N. Deposit date: 2023-07-27 Release date: 2024-04-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Design, synthesis, and biological activity of D-bishomo-1 alpha ,25-dihydroxyvitamin D 3 analogs and their crystal structures with the vitamin D nuclear receptor. Eur.J.Med.Chem., 271, 2024

与D-双同型-1α,25-二羟基维生素D3类似物54结合的维生素D受体（VDR, Vitamin D Receptor）晶体结构。描述符：(1R,3R)-5-[(2E)-2-[(4aR,5S,9aS)-4a-甲基-5-[(2R)-6-甲基-6-羟基庚-2-基]-3,4,5,6,7,8,9,9a-八氢-2H-苯并环庚烯-1-亚基]亚乙基]环己烷-1,3-二醇；核受体辅激活因子2（Nuclear receptor coactivator 2）；维生素D3受体A（Vitamin D3 receptor A）。作者：罗谢尔（Rochel, N.）。提交日期：2023-07-27；发布日期：2024-04-24；最后修改日期：2024-05-22。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.64埃（Å）。引用文献：《D-双同型-1α,25-二羟基维生素D3类似物的设计、合成与生物活性及其与维生素D核受体的晶体结构》，《欧洲医药化学杂志》（Eur.J.Med.Chem.），2024年，第271卷。