Sex Estimation Using Sexually Dimorphic Amelogenin Protein Fragments in Human Enamel

Sex estimation of human remains from demineralized blocks of tooth enamel by liquid chromatography tandem mass spectrometry (LC- MS/MS) and proteomic analysis of sexually dimorphic amelogenin peptides. The detection of the Y-isoform of amelogenin is used to estimate male sex. The combined signal intensity of the sexually dimorphic peptides from each samples of known sex is used to establish a statistical framework for the estimation of the female sex probability.

本数据集采用液相色谱-串联质谱（liquid chromatography tandem mass spectrometry，LC-MS/MS）技术结合性别二态性釉原蛋白（amelogenin）肽段的蛋白质组学分析，对脱矿牙釉质块中的人类遗骸开展性别推定。通过检测釉原蛋白的Y亚型，可判定样本为男性；利用已知性别样本的性别二态性肽段的组合信号强度，可构建用于估算女性性别概率的统计框架。