GC bias metrics for the three downsampled samples that failed to run on ascatNgs

This file contain GC bias metrics for all the samples (n = 67). The data was derived using the CollectGcBiasMetrics tool from Picard tools (https://broadinstitute.github.io/picard/). The GC bias metrics include AT_DROPOUT, representing how undercovered regions with GC content less than 50% are compared to the mean coverage; GC_DROPOUT, representing how undercovered regions with GC content greater than 50% are compared to the mean coverage; GC_NC_0_19, representing normalized coverage over quintile of GC content ranging from 0%–19%; GC_NC_20_39, representing normalized coverage over quintile of GC content ranging from 20%–39%; GC_NC_40_59, representing normalized coverage over quintile of GC content ranging from 40%–59%; GC_NC_60_79, representing normalized coverage over quintile of GC content ranging from 60%–79% and GC_NC_80_100, representing normalized coverage over quintile of GC content ranging from 80%–100. The Type column indicates whether the sample relates to the tumour or normal tissue of a given donor. The ASCAT column indicates whether ascatNgs ran on all tiers of downsampling (PASS) or failed at least in one of the downsampling tier (FAILED) for the paired normal tumour samples. The Metric column indicates the GC bias metric of interest. The value column provides the numerical value of the GC bias metric of interest for the tumour or normal sample of a particular donor.

本文件涵盖全部67个样本（n=67）的GC偏好性（GC bias）指标。该数据集通过Picard工具集中的CollectGcBiasMetrics工具生成（来源网址：https://broadinstitute.github.io/picard/）。GC偏好性指标包含以下内容：AT_DROPOUT，用于表征GC含量低于50%的区域相较平均覆盖度的覆盖不足程度；GC_DROPOUT，用于表征GC含量高于50%的区域相较平均覆盖度的覆盖不足程度；GC_NC_0_19代表GC含量区间0%–19%的五分位归一化覆盖度；GC_NC_20_39代表GC含量区间20%–39%的五分位归一化覆盖度；GC_NC_40_59代表GC含量区间40%–59%的五分位归一化覆盖度；GC_NC_60_79代表GC含量区间60%–79%的五分位归一化覆盖度；GC_NC_80_100则代表GC含量区间80%–100%的五分位归一化覆盖度。Type列用于标注样本对应供体的肿瘤组织或正常组织来源；ASCAT列用于标注配对正常-肿瘤样本中，ascatNgs是否在所有下采样层级均运行成功（PASS），或至少在一个下采样层级运行失败（FAILED）；Metric列用于指定目标GC偏好性指标类型；Value列则提供特定供体的肿瘤或正常样本对应的目标GC偏好性指标的数值。