Duox2-KO
收藏中国科技资源共享网2021-07-13 更新2026-01-30 收录
下载链接：
https://escience.org.cn/metadata/detail?cstrId=e84aa72c84b997d2d1db2ec567406e38:T009378&id=e84aa72c84b997d2d1db2ec567406e38:T009378
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资源简介：
由国家遗传工程小鼠资源库合作共建单位江苏集萃药康生物科技有限公司利用基因编辑技术，自主研发，供应，保存。应用领域为：对于自发突变纯合的小鼠不能繁殖并且先天性甲状腺功能减退（低T4，高TSH），矮小和听力受损。 垂体前叶发育不良。 耳蜗缺陷包括延迟形成内沟和Corti隧道以及增厚的覆膜。
This mouse resource was independently developed, supplied, and preserved via gene editing technology by Jiangsu GemPharmatech Co., Ltd., a cooperative partner of the National Resource Library for Genetically Engineered Mice. The key phenotypic characteristics of this model are as follows: Homozygous spontaneous mutant mice are infertile, suffering from congenital hypothyroidism (low T4, high TSH), dwarfism and hearing impairment. They also show anterior pituitary hypoplasia, with cochlear defects including delayed formation of the inner groove and tunnel of Corti as well as thickened tectorial membrane.
提供机构：
国家遗传工程小鼠资源库
创建时间：
2019-11-27
