Gut microbiota in short bowel syndrome

Massive bowel resection is a major cause of short bowel syndrome (SBS). SBS is the most common cause of intestinal failure (IF) in infants and children. IF is defined as an inability to maintain adequate enteral nutrition due to the loss of extensive part of small intestine. In this study, we traced the periodical changes of gut microbiota in an infant with SBS by illumina-based 16S rDNA sequencing analysis and compared to those in three age-matched healthy infants.

大规模肠切除术是短肠综合征（short bowel syndrome, SBS）的主要致病原因。短肠综合征是婴幼儿及儿童肠功能衰竭（intestinal failure, IF）最常见的病因。肠功能衰竭被定义为因大面积小肠缺失而无法维持充足肠内营养的状态。本研究通过基于Illumina平台的16S rDNA测序分析，追踪了一名短肠综合征患儿的肠道菌群周期性变化，并将其与3名年龄匹配的健康婴幼儿的肠道菌群变化进行了对比分析。