CERES - Meyers, Bryan, et al. Nature Genetics. 2017.

Datasets used in CERES publication.Meyers, Bryan, et al. Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics. 2017.<br><br>External data:<br>CCLE_copynumber_2013-12-03.seg.txt<br>CCLE copy number data downloaded from https://data.broadinstitute.org/ccle_legacy_data/dna_copy_number/CCLE_copynumber_2013-12-03.seg.txt<br>CCLE_RNAseq_081117.rpkm.gctCCLE gene expression data downloaded from https://data.broadinstitute.org/ccle/CCLE_RNAseq_081117.rpkm.gct<br><br>ccle2maf_081117.txtCCLE mutation data downloaded from https://data.broadinstitute.org/ccle/ccle2maf_081117.txt<br><br>Achilles_v2.20.2_GeneSolutions.gct<br>RNAi DEMETER gene dependencies downloaded from https://portals.broadinstitute.org/achilles/datasets/12/download/Achilles_v2.20.2_GeneSolutions.gct<br>CCDS.current.txtCCDS gene annotations downloaded from ftp://ftp.ncbi.nlm.nih.gov/pub/CCDS/archive/15/CCDS.current.txt<br>c2.all.v6.0.symbols.gmt MSigDB genesets downloaded from http://software.broadinstitute.org/gsea/msigdb/download_file.jsp?filePath=/resources/msigdb/6.0/c2.all.v6.0.symbols.gmt<br><br>avana_rs2.txt and gecko_rs2.txtDoench-Root scores for sgRNAs provided by authors of Doench, et al. Nat. Biotechnol. 2016. <br> wang_pool_normalized.counts.txtDownloaded from supplement of Wang, et al. Cell. 2017. <br>

本数据集用于CERES发表研究：Meyers, Bryan等学者的《拷贝数效应的计算校正可提升癌症细胞中CRISPR-Cas9必需性筛选的特异性》，发表于《自然·遗传学（Nature Genetics）》2017年。

外部数据集：
CCLE_copynumber_2013-12-03.seg.txt：癌症细胞系百科全书（CCLE）拷贝数数据，下载自https://data.broadinstitute.org/ccle_legacy_data/dna_copy_number/CCLE_copynumber_2013-12-03.seg.txt
CCLE_RNAseq_081117.rpkm.gct：CCLE基因表达数据，下载自https://data.broadinstitute.org/ccle/CCLE_RNAseq_081117.rpkm.gct
ccle2maf_081117.txt：CCLE突变数据，下载自https://data.broadinstitute.org/ccle/ccle2maf_081117.txt
Achilles_v2.20.2_GeneSolutions.gct：RNAi DEMETER基因依赖性数据，下载自https://portals.broadinstitute.org/achilles/datasets/12/download/Achilles_v2.20.2_GeneSolutions.gct
CCDS.current.txt：CCDS基因注释数据，下载自ftp://ftp.ncbi.nlm.nih.gov/pub/CCDS/archive/15/CCDS.current.txt
c2.all.v6.0.symbols.gmt：MSigDB基因集数据，下载自http://software.broadinstitute.org/gsea/msigdb/download_file.jsp?filePath=/resources/msigdb/6.0/c2.all.v6.0.symbols.gmt
avana_rs2.txt 与 gecko_rs2.txt：Doench等学者2016年发表于《自然·生物技术（Nat. Biotechnol.）》的论文所提供的单向导RNA（sgRNAs）的Doench-Root评分数据
wang_pool_normalized.counts.txt：下载自Wang等学者2017年发表于《细胞（Cell）》的论文补充材料。