DataSheet_1_Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy.pdf

BackgroundGlioma-related epilepsy (GRE) is a common symptom in patients with prefrontal glioma. Epilepsy onset is associated with functional network alterations. This study investigated alterations of functional networks in patients with prefrontal glioma and GRE.
MethodsSixty-five patients with prefrontal lobe gliomas were retrospectively assessed and classified into GRE and non-GRE groups. Additionally, 25 healthy participants were enrolled after matching for general information. Imaging data were acquired within 72 h in pre-operation. The sensorimotor network was used to delineate alterations in functional connectivity (FC) and topological properties. One-way analysis of variance and post-hoc analysis with Bonferroni correction were used to calculate differences of FC and topological properties.
ResultsAll significant alterations were solely found in the sensorimotor network. Irrespective of gliomas located in the left or right prefrontal lobes, the edge between medial Brodmann area 6 and caudal ventrolateral Brodmann area 6 decreased FC in the GRE group compared with the non-GRE group [p < 0.0001 (left glioma), p = 0.0002 (right glioma)]. Moreover, the shortest path length decrease was found in the GRE group compared with the non-GRE group [p = 0.0292 (left glioma) and p = 0.0129 (right glioma)].
ConclusionsThe reduction of FC between the medial BA 6 (supplementary motor area) and caudal ventrolateral BA 6 in the ipsilateral hemisphere and the shortening of the path length of the sensorimotor network were characteristics alterations in patients with GRE onset. These findings fill in the gap which is the relationship between GRE onset and the alterations of functional networks in patients with prefrontal glioma.
Significance StatementGlioma related epilepsy is the most common symptom of prefrontal glioma. It is important to identify characteristic alterations in functional networks in patients with GRE. We found that all significant alterations occurred in the sensorimotor network. Moreover, a decreased FC in the supplementary motor area and a shortening of the path’s length are additional characteristics of glioma-related epilepsy. We believe that our findings indicate new directions of research that will contribute to future investigations of glioma-related epilepsy onset.

背景 与胶质瘤相关的癫痫（Glioma-related epilepsy, GRE）是前额叶胶质瘤患者的常见症状。癫痫发作与功能网络改变密切相关。本研究旨在探讨前额叶胶质瘤伴发GRE患者的功能网络改变情况。
方法 本研究回顾性评估了65例前额叶胶质瘤患者，并将其分为GRE组与非GRE组。此外，按照一般信息匹配原则纳入了25名健康对照者。所有受试者均于术前72小时内完成影像学数据采集。本研究以感觉运动网络为研究对象，分析其功能连接（functional connectivity, FC）与拓扑属性的改变。采用单因素方差分析结合邦费罗尼校正的事后检验，计算功能连接与拓扑属性的组间差异。
结果 所有显著改变均仅见于感觉运动网络。无论胶质瘤位于左侧还是右侧前额叶，与非GRE组相比，GRE组内侧布罗德曼6区与尾侧腹外侧布罗德曼6区之间的功能连接均显著降低[左侧胶质瘤：p < 0.0001；右侧胶质瘤：p = 0.0002]。此外，与非GRE组相比，GRE组的最短路径长度显著缩短[左侧胶质瘤：p = 0.0292；右侧胶质瘤：p = 0.0129]。
结论 同侧半球内侧布罗德曼6区（辅助运动区）与尾侧腹外侧布罗德曼6区之间的功能连接降低，以及感觉运动网络的路径长度缩短，是GRE发作患者的特征性改变。本研究结果填补了前额叶胶质瘤患者GRE发作与功能网络改变之间关联研究的空白。
意义 胶质瘤相关性癫痫是前额叶胶质瘤最常见的症状，明确GRE患者的功能网络特征性改变具有重要意义。本研究发现所有显著改变均发生于感觉运动网络，且辅助运动区的功能连接降低与路径长度缩短是胶质瘤相关性癫痫的额外特征。我们认为本研究结果为胶质瘤相关性癫痫发作的未来研究指明了新方向。