Id3 is required for the maintenance of tissue-infiltrating alloreactive T cells in GVHD but not anti-leukemia responses [RNA-Seq]. Id3 is required for the maintenance of tissue-infiltrating alloreactive T cells in GVHD but not anti-leukemia responses [RNA-Seq]

To comprehensively identify the transcriptional regulatory pathways by Id3 during CD4 T cell activation and Th1 differentiation. Overall design: Differential expression analysis of RNA-seq data for Id3-KO and WT CD4 Th1 cells.

本研究旨在全面鉴定CD4阳性T细胞活化及Th1细胞分化过程中，分化抑制因子3（Id3）介导的转录调控通路。实验整体设计：对Id3敲除（Id3-KO）与野生型（WT）CD4阳性Th1细胞的RNA测序（RNA-seq）数据开展差异表达分析。