A genome-wide association study of total child psychiatric problems scores: summary statistics

Summary statistics for EAGLE GWAS on total child psychiatric problems scores. Data is provided in R binary format and can be loaded within R with load("total_child_psychiatric_GWAS.Rdata"). snp: SNP RS ID effect_allele: Effect allele other_allele: Other allele beta: Change in total psychiatric problem score in SD per number of effect allele se: Standard Error p: p-value n: Sample Size For more information, see PLOS ONE publication: Neumann A, Nolte IM, [...], Hartman C & Tiemeier H. A genome-wide association study of total child psychiatric problems scores. PloS one. 2022 Aug 22;17(8):e0273116. https://doi.org/10.1371/journal.pone.0273116 Abstract: Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG G > 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related traits.

针对儿童总体精神病理问题得分的EAGLE全基因组关联研究（Genome-Wide Association Study, GWAS）汇总统计量。本数据集以R二进制格式提供，可通过R语言中的`load("total_child_psychiatric_GWAS.Rdata")`命令加载。
snp：单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的RS标识符
effect_allele：效应等位基因
other_allele：其他等位基因
beta：每携带一份效应等位基因时，儿童总体精神病理问题得分的标准差变化量
se：标准误
p：p值
n：样本量
如需了解更多信息，请参阅发表在《PLOS ONE》的论文：Neumann A、Nolte IM、[...]、Hartman C与Tiemeier H. 《针对儿童总体精神病理问题得分的全基因组关联研究》. PLOS ONE. 2022年8月22日;17(8):e0273116. https://doi.org/10.1371/journal.pone.0273116
摘要：既往研究已报道多种精神障碍间存在显著遗传相关，并已检测到大量跨障碍遗传变异。为识别儿童期通用精神病理的潜在遗传变异，本研究采用总体精神病理问题得分开展全基因组关联研究。研究纳入参与早期遗传学与生命历程流行病学（EArly Genetics and Lifecourse Epidemiology, EAGLE）联盟的20个人群队列共计38418名学龄儿童，对6844199个常见单核苷酸多态性进行分析。儿童总体精神病理问题的SNP遗传力为5.4%（标准误=0.01），另有2个位点达到全基因组显著性水平：rs10767094与rs202005905。本研究还发现，既往全基因组关联研究中与神经质相关的SBF2基因，与儿童总体精神病理问题存在关联。儿童总体精神病理问题得分的遗传效应仅与常见精神障碍（注意缺陷多动障碍、焦虑障碍、抑郁障碍、失眠）的已知遗传变异存在共享（遗传相关系数rG>0.49），而与孤独症或少见成人精神障碍（精神分裂症、双相障碍、进食障碍）无显著共享遗传效应（rG G>0.29）。研究结果表明，多数常见遗传变异总体上与儿童期精神症状及相关表型相关，而非仅与特定精神症状相关。未来仍需进一步研究以明确精神障碍与相关性状间的因果关系及多效性机制。