Induction of Antigen-Specific Tolerance in Multiple Sclerosis Model without Broad Immunosuppression

Development of tolerogenic microparticle (MP) therapy made of acetalated dextran and loaded with antigenic peptide and tolerizing drug rapamycin (Rapa) to address problems with Multiple Sclerosis (MS) autoimmune disease.

本研究开发了以缩醛化葡聚糖（acetalated dextran）为载体材料、负载抗原肽（antigenic peptide）与耐受原性药物雷帕霉素（rapamycin，Rapa）的致耐受性微球（tolerogenic microparticle，MP）疗法，以解决多发性硬化症（Multiple Sclerosis，MS）这一自身免疫性疾病的治疗难题。