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Influenza A virus polymerase PA subunit endonuclease domain bound to inhibitor Compound 19a

NIAID Data Ecosystem2026-05-02 收录

抗病毒药物研发

流感病毒聚合酶抑制剂

数据链接：

https://www.rcsb.org/structure/9DOJ 数据链接链接失效反馈

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Influenza A virus polymerase PA subunit endonuclease domain bound to inhibitor Compound 19a

结合抑制剂Compound 19a的甲型流感病毒聚合酶PA亚基核酸内切酶结构域

应用场景：

创建时间：

2025-01-29

药物发现

抗病毒药物研发

Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health em

NIAID Data Ecosystem100

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins

蛇毒蛋白质

抗病毒药物研发

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifesta

Figshare2019-04-24 更新30

Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV‑2 Main Protease and Its Variants Displaying Potent Antiviral Activity

抗病毒药物研发

SARS-CoV-2 3CL蛋白酶抑制剂

The main protease (Mpro) of SARS-CoV-2 is a key drug target for the development of antiviral therapeutics. Here, we designed and synthesized a series of small-molecule peptidomimetics with various cys

NIAID Data Ecosystem20

Data Sheet 1_A hedgehog cathelicidin-derived peptide exhibits antiviral activity against herpes simplex virus type 1 infection.pdf

抗病毒药物研发

抗菌肽活性

Herpes simplex virus type 1 (HSV-1) is a widespread infectious virus that poses a substantial public health burden. With no specific curative therapy available and current antivirals providing only sy

NIAID Data Ecosystem30

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

抗病毒药物研发

RSV融合抑制剂

A novel benzoazepinequnoline (BAQ) series was discovered as RSV fusion inhibitors. BAQ series originated from compound 2, a hit from similarity-based virtual screening. In SAR exploration, benzoazepi

NIAID Data Ecosystem20

Influenza A virus polymerase PA subunit endonuclease domain bound to inhibitor Compound 19a

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