Long-term outcome in neuroZika: when biological diagnosis matters

Objectives: To characterize the full spectrum, relative frequency and prognosis of the neurological manifestations in Zika virus (ZIKV) postnatal infection.
Methods: We conducted an observational study in consecutive ZIKV-infected patients presenting with neurological manifestations during the French West Indies 2016 outbreak.
Results: Eighty-seven patients, including 6 children, were enrolled. Ninety-five percent of all cases required hospitalization. Guillain-Barré syndrome was the most frequent manifestation (46.0%) followed by encephalitis or encephalomyelitis (20.7%), isolated single or multiple cranial nerve palsies (9.2%), other peripheral manifestations (6.9%), and stroke (1.1%). Fourteen patients (16.1%) including one child, developed a mixed disorder involving both the central and peripheral nervous system. Mechanical ventilation was required in 21 cases all of whom had ZIKV RNA in at least one biological fluid. Two adult patients died due to neuroZika. Clinical follow-up (...

目的：明确寨卡病毒（Zika virus, ZIKV）产后感染中神经系统表现的完整谱、相对频率及预后特征。
方法：我们在2016年法属西印度群岛寨卡病毒暴发期间，对连续就诊的、表现出神经系统症状的寨卡病毒感染患者开展了一项观察性研究。
结果：共纳入87例患者，其中包括6名儿童。95%的病例需要住院治疗。吉兰-巴雷综合征（Guillain-Barré syndrome）是最常见的表现（46.0%），其次为脑炎或脑脊髓炎（20.7%）、孤立性单支或多支颅神经麻痹（9.2%）、其他周围神经系统表现（6.9%）及脑卒中（1.1%）。14例患者（16.1%）——包括1名儿童——出现累及中枢及周围神经系统的混合性病变。21例患者需要机械通气，所有这些患者的至少一种生物体液中均检测到ZIKV RNA。2例成年患者因神经型寨卡病毒病（neuroZika）死亡。临床随访（...