Change in accessibilities of residues at binding sites I and II on binding different ligands.

aValues for warfarin binding at Site I and ibuprofen binding at Site II are from [53].bΔASA = ASA(isolated) – ASA(complex), where ASA is the accessible surface area of a given residue. Only values >10 Å2 are reported.

a) 位点I（Site I）处华法林（warfarin）、位点II（Site II）处布洛芬（ibuprofen）的结合数值源自参考文献[53]。b) ΔASA = ASA(孤立态) – ASA(复合物态)，其中ASA（accessible surface area）指给定残基的可及表面积；仅报告数值大于10 Ų的结果。