S1 Data -

Background
Patellofemoral pain syndrome (PFPS) is a prevalent and often debilitating condition, affecting approximately 22.7% of the population and significantly contributing to knee-related disorders. It primarily impacts young athletes and sedentary individuals, impairing their quality of life and functional abilities. Despite extensive research, the optimal management strategies for PFPS remain contentious due to its multifactorial etiology and persistent symptoms. The findings of this review will guide clinical practice and future research, ultimately improving outcomes for individuals with PFPS.
Objective
This systematic review aims to evaluate the effectiveness of physiotherapy interventions in alleviating pain, enhancing functional outcomes, and improving the quality of life among runners who have been diagnosed with PFPS.
Methods
This review will be carried out on randomized controlled trials (rcts) that assess any type of physiotherapy intervention for PFPS in runners. Eligible studies must report on pain intensity, functional improvement, or quality of life outcomes. Searches will be conducted in pubmed/MEDLINE, Cochrane Library, and pedro, covering publications from May 2014 to April 2024. Two reviewers will independently screen and select studies, extract data, and assess quality using the Cochrane Risk of Bias tool. We will perform a narrative synthesis of the data, focusing on pain management, functional recovery, and quality of life improvements. Sensitivity and subgroup analyses will explore variations across study designs and participant characteristics.
Conclusion
This systematic review protocol seeks to identify effective physiotherapy interventions for managing PFPS in runners. By analyzing rcts, the review will provide evidence-based recommendations to reduce pain, improve function, and enhance quality of life. The findings will guide clinical decisions
Systematic review registration
International Prospective Register of Systematic Reviews (PROSPERO) under ID: CRD42024531888.
Date- 7/05/2024, URL https://www.crd.york.ac.uk/prospero/#recorddetails.

背景：髌股疼痛综合征（Patellofemoral pain syndrome, PFPS）是一种高发且常导致功能障碍的疾病，影响约22.7%的人群，是膝关节相关疾病的重要致病因素。该疾病主要累及青年运动员与久坐人群，会损害患者的生活质量与肢体功能。尽管已有大量相关研究，但由于其多因素病因且症状迁延不愈，髌股疼痛综合征的最优管理策略仍存在争议。本综述的研究结果将为临床实践与后续研究提供指导，最终改善髌股疼痛综合征患者的预后。
目的：本系统综述旨在评估物理治疗干预对确诊为髌股疼痛综合征的跑步者的疼痛缓解、功能结局改善以及生活质量提升的有效性。
方法：本综述将纳入针对跑步人群髌股疼痛综合征的各类物理治疗干预的随机对照试验（randomized controlled trials, RCTs）。符合纳入标准的研究需报告疼痛强度、功能改善或生活质量相关结局指标。检索将在PubMed/MEDLINE、科克伦图书馆（Cochrane Library）与PEDro数据库中进行，检索时间范围为2014年5月至2024年4月。将由两名研究者独立完成文献筛选与纳入、数据提取，并采用科克伦偏倚风险工具进行质量评估。本研究将对数据进行叙述性综合分析，重点关注疼痛管理、功能恢复与生活质量改善三个方面。敏感性分析与亚组分析将探究不同研究设计与受试者特征带来的结果差异。
结论：本系统综述方案旨在明确针对跑步人群髌股疼痛综合征的有效物理治疗管理手段。通过对随机对照试验的分析，本综述将提供基于证据的推荐方案，以减轻患者疼痛、改善肢体功能并提升生活质量。研究结果将为临床决策提供指导。
系统综述注册信息：本研究已在国际系统综述前瞻性注册平台（International Prospective Register of Systematic Reviews, PROSPERO）注册，注册编号为CRD42024531888。注册日期：2024年5月7日，注册网址：https://www.crd.york.ac.uk/prospero/#recorddetails.