2-year Longitudinal Analyses of Peripheral Blood RNA in Huntington's Disease gene-positive and control subjects. 2-year Longitudinal Analyses of Peripheral Blood RNA in Huntington's Disease gene-positive and control subjects

Samples collected in the course of the TRACK HD study and used to analyse association between gene expression in blood and symptomatic progression of Huntington's disease Longitudinal analysis of UHDRS TMS versus gene expression in individual subjects followed by cross-sectional comparisons across phenotype groups at each timepoint Overall design: Year 1: 24 Controls, 17 Huntington's mutation-positive presymptomatic far from age of predicted onset (Pre-A), 18 Huntington's mutation-positive presymptomatic near to age of predicted onset (Pre-B), 18 Manifest Huntington's disease Stage 1 (zHD1), 19 Manifest Huntington's disease Stage 2 (zHD2); Year 3: 20 Controls, 15 pre-A, 15 pre-B, 16 zHD1, 16 zHD 2 contributor: TRACK-HD Investigators

本数据集采集自TRACK HD研究队列，用于分析血液基因表达与亨廷顿舞蹈症（Huntington's disease）症状进展之间的关联。针对个体受试者开展统一亨廷顿舞蹈症评定量表运动总分（Unified Huntington's Disease Rating Scale Total Motor Score, UHDRS TMS）与基因表达的纵向分析，随后在每个时间点对不同表型组进行横断面比较。
整体设计：
第一年：24名健康对照者、17例远离预期发病年龄的亨廷顿基因突变阳性症状前受试者（Pre-A）、18例接近预期发病年龄的亨廷顿基因突变阳性症状前受试者（Pre-B）、18例1期显性亨廷顿舞蹈症患者（zHD1）、19例2期显性亨廷顿舞蹈症患者（zHD2）；
第三年：20名健康对照者、15例Pre-A受试者、15例Pre-B受试者、16例zHD1患者、16例zHD2患者
数据贡献者：TRACK-HD研究团队