Menstrual flow as a non-invasive source of endometrial organoids

Organoid cultures derived from menstrual flow faithfully replicate secretory phase endometrial glands and provide a novel, non-invasive technique for the clinical assessment of endometrial function. Paired organoid cultures derived from scratch biopsies and ensuing menstrual flow share the same transcriptome signature, responses to early pregnancy hormones, and pathological changes in cases of early-pregnancy loss. The technique opens new avenues for investigating endometrial function in cases of subfertility and gynaecological disorders.

源自经血的类器官（Organoid）培养体系可精准复现分泌期子宫内膜腺体的特征，为子宫内膜功能的临床评估提供了一种全新的非侵入性技术手段。分别源自子宫内膜刮诊活检与后续经血的配对类器官培养体系，在转录组特征、对早孕激素的应答反应以及早期妊娠丢失病例中的病理改变这三方面均保持一致。该技术为探究亚生育人群与妇科病症患者的子宫内膜功能开辟了全新研究路径。