Additional file 3 of microRNA profiling in the Weddell seal suggests novel regulatory mechanisms contributing to diving adaptation

Additional file 3: Table S2. Overview of all samples used in this study. Table S3. number of reads mapped to each miRNA locus across all samples. Table S4. number of reads mapped to each miRNA locus across all samples. Table S5. Tissue-specific differential expression statistics considering all pairwise tissue comparisons (brain_heart, brain_muscle, brain_plasma, heart_muscle, heart_plasma, muscle_plasma). Fold change refers to changes from tissue_1 to tissue_2, as defined by column H. Table S6. Age-specific differential expression statistics considering all tissues together. Fold change refers to changes from pup to adult (i.e. positive sign indicates upregulation in adult). Table S7. Tissue-specific differential expression statistics for developmental stage (adult versus pup). Table S8. Significant pathway enrichments in brain, heart, and muscle for mRNA targets of all microRNAs differentially expressed in Weddell seal maturation. Table S9. Enriched KEGG pathways associated with mRNA targets of novel miRNAs upregulated (+) or downregulated (−) in four Weddell seal sample types. Table S10. Number of significant pathway enrichments annotated to mRNA targets of novel Weddell seal microRNAs that were elevated (+) or decreased (−) in four sample types.

附加文件3：表S2。本研究所用全部样本概况。表S3：所有样本中比对至每个微小RNA (miRNA) 位点的读段数量。表S4：所有样本中比对至每个微小RNA (miRNA) 位点的读段数量。表S5：针对所有组织两两比对组合（脑-心脏、脑-肌肉、脑-血浆、心脏-肌肉、心脏-血浆、肌肉-血浆）的组织特异性差异表达统计结果。倍数变化 (Fold change) 指从组织1到组织2的表达量变化，由第H列定义。表S6：整合所有组织的年龄特异性差异表达统计结果。倍数变化 (Fold change) 指从幼崽（pup）到成体的表达量变化，即符号为正则表示成体中表达上调。表S7：针对发育阶段（成体 vs 幼崽）的组织特异性差异表达统计结果。表S8：威德尔海豹（Weddell seal）成熟过程中差异表达的所有微小RNA (miRNA) 靶信使RNA (mRNA) 在脑、心脏及肌肉中的显著通路富集结果。表S9：在四种威德尔海豹（Weddell seal）样本类型中上调（+）或下调（−）的新型微小RNA (miRNA) 靶信使RNA (mRNA) 相关的富集KEGG通路。表S10：在四种样本类型中表达升高（+）或降低（−）的威德尔海豹（Weddell seal）新型微小RNA (miRNA) 靶信使RNA (mRNA) 所注释到的显著通路富集数量。