Demographic and clinical characteristics of the study groups included in the various analyses.

The three virulence analyses could be performed on different, albeit overlapping, subsets of the cohort. In the early years, RNA measurements were not yet available, while recently enrolled patients do not have sufficient data points for the calculation of the CD4 slope. Statistics of the linear regression model of the CD4 slope refer to the subset stripped of outliers below the 5% and above the 95% percentiles; this subset was used in the regression analyses. The mixed-effect model accommodated more patients due to less stringent inclusion criteria. The small number of IDUs in the viral setpoint analysis reflects their diminished proportion in the cohort by the time RNA assays have become available.IDU, intravenous drug users; MSM, men having sex with men.

三项毒力分析可分别针对本研究队列的不同子集开展，各子集间虽存在部分重叠。研究早期阶段暂未开展RNA检测，而新近入组的患者则缺乏足够的数据点以计算CD4斜率。CD4斜率的线性回归模型统计结果基于剔除了5%以下及95%以上百分位异常值的子集，该子集被用于本次回归分析。由于纳入标准更为宽松，混合效应模型（mixed-effect model）可纳入更多患者。病毒设定点分析中纳入的静脉注射吸毒者（intravenous drug users, IDU）数量较少，这反映出在RNA检测技术普及之时，该群体在本队列中的占比已有所下降。注：IDU即静脉注射吸毒者（intravenous drug users）；MSM即男男性行为者（men having sex with men）。