Rat colonic tissue transcriptome with dietary intervention by freeze-dried baby spinach (10% w/w in AIN-93 diet)

Polyposis in rat colon (Pirc) model harbors an Apc mutation and mimics human Familial Adenomatous Polyposis (FAP), allowing for intervention studies (e.g., PMID: 27706811, PMID: 30643017). RNA-sequencing of adenomatous polyps and normal colon identified genes altered by dietary spinach consumption. RNA-seq analyses of transcriptome from rat colon tumors and normal colon samples.

大鼠结肠息肉病（Pirc）模型携带Apc基因突变，其表型模拟人类家族性腺瘤性息肉病（Familial Adenomatous Polyposis, FAP），可用于相关干预研究（例如参考文献PMID: 27706811、PMID: 30643017）。本数据集通过对腺瘤性息肉与正常结肠组织进行RNA测序（RNA-sequencing），鉴定出膳食菠菜摄入所调控的差异表达基因；同时涵盖大鼠结肠肿瘤与正常结肠样本的转录组（transcriptome）RNA测序（RNA-seq）分析数据。