Investigating the effects of Ceylon cinnamon water extract and metformin on HepG2 cells for type 2 diabetes therapy

performing high-throughput RNA sequencing (RNA-Seq) transcriptomic analysis of hepatic cells after metformin or CWE treatment to identify changes in diabetes-related gene expression. Outcomes of this project provide evidence for the effectiveness of Ceylon cinnamon water extract compared to the current standard therapy for type 2 diabetes, metformin.

本研究对经二甲双胍或锡兰肉桂水提取物（Ceylon cinnamon water extract，CWE）处理后的肝细胞开展高通量RNA测序（RNA-Seq）转录组分析，以鉴定糖尿病相关基因的表达变化。本项目的研究结果可为锡兰肉桂水提取物相较于当前2型糖尿病标准治疗药物二甲双胍的疗效提供科学佐证。