Dataset from A Phase 3, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients With Moderately Severe to Severe Nonproliferative Diabetic Retinopathy

The primary objective of the study is to assess the efficacy of intravitreal (IVT) aflibercept compared to sham treatment in the improvement of moderately severe to severe nonproliferative diabetic retinopathy (NPDR).The secondary objectives of the study are:* To characterize the safety of IVT aflibercept in patients with moderately severe to severe NPDR* To determine if IVT aflibercept will prevent the worsening of diabetic retinopathy and reduce the incidence of DME* To determine the anatomic effects of IVT aflibercept in patients with moderately severe to severe NPDR

本研究的主要目的为评估玻璃体内（intravitreal，IVT）阿柏西普与假治疗相比，在改善中重度至重度非增生性糖尿病视网膜病变（nonproliferative diabetic retinopathy，NPDR）方面的疗效。本研究的次要目的如下：
* 明确中重度至重度非增生性糖尿病视网膜病变患者接受玻璃体内阿柏西普治疗的安全性特征
* 探究玻璃体内阿柏西普是否可延缓糖尿病视网膜病变进展，并降低糖尿病性黄斑水肿（diabetic macular edema，DME）的发生率
* 分析玻璃体内阿柏西普对中重度至重度非增生性糖尿病视网膜病变患者的解剖学影响