Genomic characterization of MMTV-PyVT transgenic mice

MMTV-PyVT transgenic mice have been established as a multistage model for mammary carcinoma and progression. We used WES to characterize somatic genomic alterations in murine mammary tumors from two MMTV-PyVT transgenic mice.

MMTV-PyVT转基因小鼠（MMTV-PyVT transgenic mice）已被确立为研究乳腺癌发生与进展的多阶段模型。本研究采用全外显子测序（Whole Exome Sequencing，WES），对两只MMTV-PyVT转基因小鼠的乳腺肿瘤体细胞基因组变异进行了特征分析。