Palladium-Catalyzed Selective Fluorination of o‑Carboranes

A Pd­(II)-catalyzed direct selective fluorination reaction of carboranes using a F+ reagent has been developed, leading to a series of polyfluorocarboranes in high isolated yields. The mechanism involving electrophilic B–H activation, oxidation of Pd­(II) by F+ species, and reductive elimination is proposed.

本研究开发了一种二价钯（Pd(II)）催化、以氟正离子（F+）试剂为氟化剂的碳硼烷（carboranes）直接选择性氟化反应，可得到一系列多氟代碳硼烷（polyfluorocarboranes），且产物均获得较高的分离产率。该反应的机理被提出包含亲电B-H键活化（electrophilic B–H activation）、氟正离子物种对二价钯的氧化以及还原消除（reductive elimination）三个关键步骤。