Dataset from Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus (ADVN AMP01)

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Recent studies have demonstrated that the skin of people with AD my have decreased antimicrobial peptide (AMP) expression. The purpose of this study is to compare smallpox virus replication and the number of AMPs and other antiviral molecules in people with AD, as compared to those seen in people with psoriasis or asthma, or healthy individuals.

特应性皮炎（Atopic dermatitis, AD）是一类以复发性皮肤病毒感染为特征的慢性炎症性皮肤疾病。近期研究表明，特应性皮炎患者的皮肤中抗菌肽（antimicrobial peptide, AMP）的表达水平有所降低。本研究旨在对比特应性皮炎患者与银屑病患者、哮喘患者及健康个体的天花病毒复制情况，以及抗菌肽与其他抗病毒分子的表达水平差异。