Comparison of gene expression profiles of RNA-seq data from lungs of wild-type mice and RBM47KI mice

To investigate the function of RBM47-ISGylation in mouse lungs, we generated an RBM47 knock-in mouse in which K329 and K332 were mutated to ISGylation-deficient arginine (K329R;K332R). We then performed gene expression analysis using data obtained from RNA-seq of lung tissues from wild-type and pure mice from the same litter. Gene expression profile of RBM47 K329R;K332R KI mouse lung RNA-seq data.

为探究RBM47的ISG化修饰（ISGylation）在小鼠肺部中的功能，我们构建了一株RBM47敲入（knock-in）小鼠，该小鼠的K329与K332位点被突变为ISG化修饰缺陷型的精氨酸（K329R;K332R）。随后我们利用同窝野生型小鼠与纯合小鼠肺部组织的RNA测序（RNA-seq）数据开展基因表达分析。本数据集包含RBM47 K329R;K332R敲入小鼠肺部组织的RNA-seq基因表达谱数据。