Orthrus: Towards Evolutionary and Functional RNA Foundation Models

Orthrus is a mature RNA model for RNA property prediction. It uses a Mamba encoder backbone, a variant of state-space models specifically designed for long-sequence data, such as RNA.

Two versions of Orthrus are available:

4-track base version: Encodes the mRNA sequence with a simplified one-hot approach.

6-track large version: Adds biological context by including splice site indicators and coding sequence markers, which is crucial for accurate mRNA property prediction such as RNA half-life, ribosome load, and exon junction detection.

Orthrus是一款用于RNA属性预测的成熟模型。该模型采用Mamba编码器骨干网络，作为专为长序列数据（如RNA）设计的状态空间模型（state-space models）变体。

目前Orthrus提供两个版本：

4-track基础版本：采用简化独热编码方式对mRNA序列进行编码。

6-track大尺寸版本：通过加入剪接位点标识与编码序列标记来补充生物学上下文信息，这对于精准预测mRNA属性（如RNA半衰期、核糖体负载以及外显子连接检测）至关重要。