Activity of chimp neural crest enhancer near COL13A1 in E11.5 transgenic mouse embryo – Tg(panTro4_chr10: 68198369-68199194::LacZ).

Tg(panTro4_chr10: 68198369- 68199194::LacZ) chimp neural crest enhancer with activity in the forebrain, midbrain, hindbrain, trigeminal (V) ganglion, and midgut. This enhancer lacks the expression in the frontonasal process, optic cup, branchial arches, heart field, limb buds, and somites that is observed with the equivalent human enhancer, demonstrating a human species-specific bias when comparing these two species.

Tg(panTro4_chr10:68198369-68199194::LacZ)黑猩猩神经嵴增强子（neural crest enhancer），在前脑（forebrain）、中脑（midbrain）、后脑（hindbrain）、三叉神经节（trigeminal (V) ganglion）及中肠（midgut）中具有活性。该增强子缺乏额鼻突（frontonasal process）、视杯（optic cup）、鳃弓（branchial arches）、心区（heart field）、肢芽（limb buds）和体节（somites）中的表达——这些表达在等效的人类增强子中可观察到，这表明在比较这两个物种时存在人类物种特异性偏好。