Recent advances in photodynamic therapy combined with chemotherapy for cervical cancer: a systematic review

Despite the evidence that photodynamic therapy (PDT) associated with chemotherapy presents great potential to overcome the limitations of monotherapy, little is known about the current status of this combination against cervical cancer. This systematic review aimed to address the currently available advances in combining PDT and chemotherapy in different research models and clinical trials of cervical cancer. We conducted a systematic review based on PRISMA Statement and Open Science Framework review protocol using PubMed, Web of Science, Embase, Scopus, LILACS, and Cochrane databases. We selected original articles focusing on ‘Uterine Cervical Neoplasms’ and ‘Photochemotherapy and Chemotherapy’ published in the last 10 years. The risk of bias in the studies was assessed using the CONSORT and SYRCLE tools. Twenty-three original articles were included, focusing on HeLa cells, derived from endocervical adenocarcinoma and on combinations of several chemotherapeutics. Most of the combinations used modern drug delivery systems for improved simultaneous delivery and presented promising results with increased cytotoxicity compared to monotherapy. Despite the scarcity of animal studies and the absence of clinical studies, the combination of chemotherapy with PDT presents a potential option for cervical cancer therapy requiring additional studies. https://doi.org/10.17605/OSF.IO/WPHN5

尽管已有研究证实，光动力疗法（Photodynamic Therapy, PDT）联合化疗在克服单一疗法局限方面极具潜力，但目前学界对该联合疗法用于宫颈癌治疗的研究现状仍知之甚少。本系统综述旨在梳理当前宫颈癌领域不同研究模型与临床试验中，光动力疗法联合化疗的研究进展。本研究遵循PRISMA声明与开放科学框架（Open Science Framework, OSF）综述方案，依托PubMed、Web of Science、Embase、Scopus、LILACS及Cochrane数据库开展系统综述。本研究筛选了近10年发表的、以"子宫颈肿瘤（Uterine Cervical Neoplasms）"与"光化学疗法与化疗"为主题的原创性研究论文。采用CONSORT与SYRCLE工具对纳入研究的偏倚风险进行评估。最终纳入23篇原创研究论文，研究对象涵盖源自宫颈内膜腺癌的海拉（HeLa）细胞，以及多种化疗药物联合光动力疗法的方案。多数联合疗法采用了现代化药物递送系统以实现同步给药，且相较于单一疗法，此类联合方案展现出更优异的细胞毒性与应用前景。尽管目前动物研究较为匮乏，且尚无临床研究，但光动力疗法联合化疗仍是宫颈癌治疗的潜在候选方案，有待开展更多后续研究。https://doi.org/10.17605/OSF.IO/WPHN5