CircETFA Upregulates CCL5 by Sponging miR-612 and Recruiting EIF4A3 to Promote Hepatocellular Carcinoma. CircETFA Upregulates CCL5 by Sponging miR-612 and Recruiting EIF4A3 to Promote Hepatocellular Carcinoma

In order to identify circRNAs involved in HCC tumorigenesis, we performed circular RNA microarray analysis on three pairs of total RNA from HCC patient plasma and healthy controls. A total of 5122 differentially expressed circRNAs were identified (FC ≥ 2 or FC ≤ -2, P-value ≤ 0.05) . Among them, 4162 circRNAs were significantly up-regulated, and 960 circRNAs were significantly down-regulated. Overall design: three pairs of total RNA from HCC patient plasma and healthy controls

为鉴定参与肝细胞癌（Hepatocellular Carcinoma，HCC）发生的环状RNA（circular RNA，circRNA），我们对3对肝细胞癌患者血浆与健康对照的总RNA开展了环状RNA芯片分析。最终共鉴定出5122个差异表达环状RNA，筛选标准为差异倍数（fold change，FC）≥2或≤-2，P值≤0.05；其中4162个环状RNA显著上调，960个环状RNA显著下调。整体实验设计：3对肝细胞癌患者血浆与健康对照的总RNA样本。