New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives Descriptor: 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Pace, J, Chisum, K, Rosowsky, A. Deposit date: 2006-02-09 Release date: 2006-12-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins, 65, 2006

二氢叶酸还原酶相互作用新进展：卡氏肺孢子虫与小鼠二氢叶酸还原酶（Dihydrofolate reductase, DHFR）结合烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及两种强效甲氧苄啶（Trimethoprim）衍生物的复合物分析
描述物：2,4-二氨基-5-[2-甲氧基-5-(4-羧基丁氧基)苄基]嘧啶、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）
作者：Cody, V、Pace, J、Chisum, K、Rosowsky, A
提交日期：2006年2月9日
发布日期：2006年12月26日
最后修改日期：2023年8月30日
实验方法：X射线衍射（分辨率2.1埃）
引用：《二氢叶酸还原酶相互作用新进展：卡氏肺孢子虫与小鼠DHFR结合NADPH及两种强效5-(ω-羧基(烷氧基)甲氧苄啶衍生物)复合物的分析》揭示了构象与活性的相关性及新型平行环堆叠相互作用，《Proteins》，2006年，第65卷