Electrophysiological evaluation of carpal tunnel syndrome female patients after vitamin D replacement

Abstract Objective: The effects of vitamin D on the central and peripheral nervous system continue to be investigated today. In the present study, we aimed to evaluate pain and electrophysiologic response in patients with carpal tunnel syndrome (CTS) who have undergone replacement therapy due to vitamin D deficiency. Methods: Fifty female patients diagnosed with mild and moderate CTS and accompanied by vitamin D deficiency were included in this study. Nerve conduction study (NCS) was performed before and after vitamin D replacement, and the patient’s pain was evaluated with Visual Analogue Scale (VAS). Results: When NCS were compared before and after treatment, there was a statistically significant improvement in the median distal sensory onset latency (DSOL) and sensory conduction velocity (CV) and motor distal latencies (DML) values (p=0.001; p<0.001; p=0.001, respectively). At the same time, there was a decrease in the VAS values in patients (p<0.001). When the two groups were compared there was an improvement in DSOL and sensory CV in both groups, but in DML only in moderate CTS group. Conclusion: In this study, it was shown that mild and moderate CTS patients had an improvement in pain and electrophysiological parameters after vitamin D replacement. Replacing vitamin D in early stages of CTS may be beneficial.

目的：当前，维生素D对中枢及外周神经系统的影响仍在持续研究中。本研究旨在评估因维生素D缺乏接受替代治疗的腕管综合征（Carpal Tunnel Syndrome, CTS）患者的疼痛与电生理反应。
方法：本研究纳入50例确诊为轻中度腕管综合征（Carpal Tunnel Syndrome, CTS）且合并维生素D缺乏的女性患者。分别于维生素D替代治疗前后开展神经传导研究（Nerve Conduction Study, NCS），并采用视觉模拟评分法（Visual Analogue Scale, VAS）评估患者的疼痛程度。
结果：对比治疗前后的神经传导研究结果可见，正中神经远端感觉潜伏期（distal sensory onset latency, DSOL）、感觉传导速度（sensory conduction velocity, CV）及运动远端潜伏期（distal motor latencies, DML）指标均出现具有统计学意义的改善（分别对应p=0.001、p<0.001、p=0.001）。同时，患者的VAS评分均有所降低（p<0.001）。分组对比后发现，两组患者的DSOL与感觉传导速度均得到改善，但运动远端潜伏期的改善仅见于中度腕管综合征组。
结论：本研究结果显示，轻中度腕管综合征患者在接受维生素D替代治疗后，其疼痛症状与电生理参数均得到改善。在腕管综合征早期阶段补充维生素D或可带来临床获益。