Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG. Rattus norvegicus

Aging is associated with a decline in hippocampal mediated learning and memory, a process wich can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioral tests to assess thier hippocampal function. Overall design: We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction.

衰老是与海马体（hippocampus）介导的学习记忆能力衰退相关的生理过程，该过程可通过饮食（热量）限制得到改善。我们采用Affymetrix基因表达分析（Affymetrix）技术，对接受饮食限制的中年（18月龄）和老年（28月龄）大鼠的海马体三个亚区（CA1区、CA3区、齿状回（DG））的基因表达变化进行监测。在用于评估海马体功能的行为学测试中，老年大鼠被划分为良好表现组（GP）与较差表现组（PP）。实验总体设计：我们采用Affymetrix基因表达分析（Affymetrix）技术，对接受饮食限制的中年（18月龄）和老年（28月龄）大鼠的海马体三个亚区（CA1区、CA3区、齿状回（DG））的基因表达变化进行监测。