Endocardial HDAC3 is required for myocardial trabeculation [miRNA-seq]. Endocardial HDAC3 is required for myocardial trabeculation [miRNA-seq]

To investigate the microRNA regulated in the endocardial cells, we performed high-throughput profiling analysis using small RNA-Seq data obtained from Hdac3 CRISPR knockout mouse cardiac endothelail cells Overall design: Comparative profiling analysis of RNA-seq data for CTL (EV) and HDAC3 knockout (Hdac3 KO) in mouse cardiac endothelial cell

为探究心内膜细胞中受调控的微小RNA（microRNA），我们利用来自Hdac3 CRISPR敲除小鼠心脏内皮细胞的小RNA测序（small RNA-Seq）数据开展了高通量表达谱分析。
实验设计：对小鼠心脏内皮细胞中对照组（CTL，空载载体EV）与HDAC3敲除组（Hdac3 KO）的RNA测序数据进行对比表达谱分析。