Data_Sheet_1_Traditional Chinese medicine constitution and sarcopenia: a cross-sectional study.doc

ObjectiveSarcopenia is a gradually advancing systemic disorder affecting skeletal muscles, primarily distinguished by diminished muscle mass and functional decline. As of present, a universally accepted diagnostic criterion for sarcopenia has yet to be established. From the perspective of the constitution theory in traditional Chinese medicine (TCM), the Yin-deficiency constitution is believed to have a significant correlation with the development of sarcopenia. The primary objective of this study was to examine the potential association between sarcopenia and Yin-deficiency constitution.
MethodsThe present study is a cross-sectional analysis. The Asian Working Group for Sarcopenia (AWGS) recommended a diagnostic criterion for sarcopenia. A total of 141 participants over 50 years of age were diagnosed with sarcopenia. To determine the constitution of each patient, classification and determination standards were used in traditional Chinese medicine. In this study, a combination of logistic regression and propensity score matching (PSM) was employed to analyze a dataset comprising 1,372 eligible observations. The diagnostic efficacy of the test in distinguishing sarcopenia was assessed through receiver operating characteristic (ROC) curve analysis.
ResultsThe relationship between Yin-deficiency constitution and sarcopenia was examined using logistic regression analysis. In the crude model, the odds ratio (OR) was found to be 3.20 (95% confidence interval [CI]: 1.70–6.03). After adjusting for various confounding factors, including gender, sex, 6 m walking test/(m/s), SMI, and maximum grip strength/kg, the OR increased to 9.70 (95% CI: 3.20–69.38). The associations between seven other biased traditional Chinese medicine (TCM) constitutions and sarcopenia were not found to be statistically significant in the fully adjusted model. The propensity score matching (PSM) analysis yielded consistent results with the logistic regression analysis. Receiver operating characteristic (ROC) curve analysis showed that the AUC of the Yin-deficiency constitution combined with age and gender reached 0.707.
ConclusionAmong the nine TCM constitutions examined, the Yin-deficiency constitution demonstrates an independent association with sarcopenia. Yin-deficiency constitution may serve as a potential risk factor for the development of sarcopenia. To establish a causal relationship, further experimental investigations are warranted. The diagnostic performance of sarcopenia is effectively demonstrated by the Yin-deficiency constitution combined with age and gender.

研究背景与目的：肌少症（Sarcopenia）是一种逐渐进展的全身性骨骼肌疾病，核心特征为肌肉量减少与肌肉功能衰退。截至目前，全球尚未形成统一认可的肌少症诊断标准。基于中医体质理论（constitution theory in traditional Chinese medicine, TCM），现有研究认为阴虚体质（Yin-deficiency constitution）与肌少症的发生发展存在显著关联。本研究旨在探讨肌少症与阴虚体质之间的潜在相关性。
研究方法：本研究为横断面分析。采用亚洲肌少症工作组（Asian Working Group for Sarcopenia, AWGS）推荐的肌少症诊断标准。本研究共纳入1372名合格受试者，其中141名50岁以上的受试者确诊为肌少症。所有受试者的中医体质分型均依据中医体质分类判定标准完成。本研究联合采用Logistic回归（logistic regression）与倾向得分匹配（propensity score matching, PSM）方法，对该数据集进行分析。通过受试者工作特征（receiver operating characteristic, ROC）曲线分析，评估相关指标鉴别肌少症的诊断效能。
研究结果：本研究通过Logistic回归分析探讨了阴虚体质与肌少症的关联。在粗模型中，比值比（odds ratio, OR）为3.20（95%置信区间[CI]：1.70~6.03）。在校正性别、6米步行测试速度（m/s）、SMI及最大握力（kg）等多项混杂因素后，OR值升至9.70（95% CI：3.20~69.38）。在完全校正模型中，其余7种中医偏颇体质与肌少症的关联均未达到统计学显著性。倾向得分匹配分析结果与Logistic回归分析结果一致。受试者工作特征曲线分析显示，阴虚体质联合年龄与性别构建的模型的曲线下面积（AUC）达0.707。
研究结论：在所纳入的9种中医体质中，阴虚体质与肌少症存在独立相关性。阴虚体质可能是肌少症发生发展的潜在危险因素。后续需开展进一步实验研究以明确二者间的因果关系。阴虚体质联合年龄与性别可有效评估肌少症的诊断效能。