Role of Gpnmb in response to virally expressed mutant SNCA

Effect of Gpnmb knockout on development of differential expression in AAV-aSyn model was studied. The "samid" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0036339 RNA from contralateral or ipsilateral whole striatum or midbrain of male mice 10 weeks after injection with AAV expressing either human aSyn-A53T or null virus.

本研究探究了Gpnmb基因敲除对腺相关病毒（AAV）介导的αSyn模型中差异表达谱发展过程的影响。“samid”样本属性为基因泰克（Genentech）内部定义的样本标识符。该项目在基因泰克ExpressionPlot数据库中的编号为PRJ0036339。实验样本取自雄性小鼠：在注射表达人源αSyn-A53T或空载体病毒的AAV 10周后，采集其对侧或同侧的全纹状体与中脑组织并提取总RNA。